On 27 November 2020, researchers across Europe will meet the public (mostly online) and showcase their work through hands-on experiments, science shows, games, quizzes, competitions, exhibitions, and digital activities. It’s the European Researchers’ Night!
RiskGONE partners are participating in some of these important events, aimed to shorten the gap between research and the general public by raising awareness on how different kinds of nanomaterials are used in daily applications and how we can manage the risks that some of them pose to the environment and human health.
Dechema LIVE Session 1 (13:00-14:00 CET)
Dechema LIVE Session 2 (18:00-19:00 CET)
Find the aganda and links: https://riskgone.eu/category/european-researchers-night-activities/
Was ist Nanotechnologie und wo wird sie eingesetzt? Wer entscheidet, ob die Produkte sicher sind?
Nanotechnologie ermöglicht neue Produkteigenschaften und bringt neuartige Anwendungen mit sich. Verbraucher*innen finden vermehrt Nanotechnologie in unterschiedlichen Produkten wie z.B. Kosmetika oder Elektronik. Doch wie sicher sind die Produkte für Mensch und Umwelt, und wer entscheidet das? Wieviel Risiko nehmen wir in Kauf, wenn es um neue, innovative Produkte geht? Wie findet man sich zurecht im Informationsdschungel im digitalen Zeitalter? Diese Fragen erforscht das europäische Projekt “Gov4Nano”. Tauschen Sie sich mit uns aus!
Veranstaltungsformat: Workshop (teilweise in in englischer Sprache)
It is the
task of hazard research and of toxicology to uncover detrimental effects. Once
a substantial knowledge has been gained, it is important to shift gears and try
to look at the problem from the other side: What is safe? This change in
perspective is necessary to allow focusing on genuinely problematic materials
and not focus too much work on less worrisome entities, merely because there is
large body of literature about them.
The group of Albert Duschl from The Paris-Lodron University of Salzburg (PLUS), one of NANORIGO project partner, has recently published a review that addresses this issue with respect to the immunosafety of nanomaterials: Himly M, Geppert M, Hofer S, Hofstätter N, Horejs-Höck J, Duschl A. 2020. When would immunologists consider a nanomaterial to be safe? Recommendations for planning studies on nanosafety. Small. DOI:10.1002/smll.201907483. The paper tries to answer which data are needed to consider a nanomaterial as – from an immunological point of view – rather harmless. Of course, this does not cover other issues like genotoxicity of developmental toxicity, but since the immune system is often the first and certainly the professional responder upon exposure to nanoparticles, it is an important part of safety assessment.
The authors recommend to fully cover three aspects in the design of a
A stringent testing for
contamination with Endotoxin / LPS is required to exclude that these powerful
proinflammatory agents elicit reactions that can be falsely attributed to the
particles tested. Due to assay interference it is necessary to use two
different tests relying on different principles. The sensitivity of the test
needs to match the sensitivity of the relevant cell, organ or species. Note
that the sensitivity of human Dendritic cells is 0.2 EU/ml.
The dose needs to be justified by
applying the same dose in vitro that may also be acting in vivo. The dose
considered here is the dose that reaches a cell – NP per cell would be good expression.
This requires to calculate which dose of nanoparticles is “seen” by cells that
e.g. adhere to the bottom of a well. Dose per m² would in this case be a good
measure, but dose per m³ would be not. A second calculation is needed to
estimate the dose to which e.g. a lung epithelial cell of a human is exposed,
which again is not the same as particles/m³.
If markers of cell stress or of
inflammation are observed in absence of proinflammatory contaminants and at a
dose that occurs in real life, then it needs to be checked whether this
represents an immune reaction or merely a homeostatic fluctuation. It is easy
to produce artifacts; for example, cells go into cell stress when they are
handled due to the temperature shock. This analysis may require some help for
experts, while the first two points can be addressed by any experimenter.
Within NANORIGO, we specifically address the second point, for example by producing an equivalence dose library for tissue-delivered dose, that will support the RGF and its users. Work with the partners should allow us to further improve this library and make it user-friendly.
NANORIGO co-organise the Venice Nano Training School in partnership with the other H2020 funded projects (BIORIMA, Gov4Nano, GRACIOUS, NanoInformaTIX, PATROLS, and RiskGONE) and celebrates its 10th anniversary. The event will take place in San Servolo (Venice, Italy) on 22nd – 27th of March 2020.
The School will feature keynote speeches,
hands-on sessions and a dedicated Young Scientist Forum Day (23rd March) during
which early career researchers (PhD students, PhD candidates and Post-Docs)
will have the opportunity to present their work. Abstract submissions opened
until the 10th of December 2019.
The School week will include a variety of
hands-on sessions aimed to transfer state-of-the-art knowledge on a variety of
topics from key experts to the new generation of nano-environmental, health and
safety, and biomedicine professionals, using interprofessional education.
A variety of networking activities (a special
10th anniversary welcome cocktail, social event and a social dinner) will
enable plenty of time and opportunities for you to widen your network and
foster academic exchange.
Hazard to Human Health & Environment, Fate
& Exposure Assessment, Nanomedicine: from the lab to the market, Modelling,
Grouping & Read Across Approaches, Risk Governance
Draft School Agenda
A draft version of the school agenda is
NANORIGO was presented by Socieade Portuguesa de Inovação (SPI), one of the NANORIGO project partner which was invited to the EuroNanoForum 2019 (https://www.euronanoforum2019.eu/) as NANO2ALL project Coordinator to present the NANO2ALL (http://www.nano2all.eu/) project ROADMAP: FOR A MORE INCLUSIVE NANOTECHNOLOGY DEVELOPMENT IN EUROPE. The presentation was delivered by Dr. Olga Glumac, SPI consultant in the International Area under the Pillar 2 – NANO for People and within session 2.3 Nanotechnology for Society on June 12th in Bucharest, Romania.
Over the past decades, awareness has grown that the impact of technologies is not always predictable, and unintended or unforeseeable consequences might occur. This unpredictability is inherent in the increasing complexity of new and emerging technologies (including nanotechnology) and their development processes. Inclusive (societal engagement) approaches implemented under the terms of responsible research and innovation (RRI) can enable the identification and integration of inputs from stakeholders and the public into decision-making on research and innovation (R&I), contributing to the development of socially acceptable and desirable research and products.
NANO2ALL included diverse mapping and participatory activities (including citizen and multi-stakeholder dialogues across Europe) to explore what is required to foster the implementation of such inclusive approaches in nanotechnology development in Europe. NANO2ALL found that there are several conditions that have to be in place simultaneously in order to truly enhance societal engagement across nanotechnology R&I value chains. Outcomes from the mapping and participatory activities and the identified conditions were further explored through desk research and expert consultation. Key findings and recommended actions were developed into a roadmap. The recommended actions are to be undertaken by EU-level and national decision-makers for creating the necessary conditions for enhanced inclusiveness in nanotechnology R&I decision-making processes.
NANORIGO was presented as an example of on-going Horizon 2020 project that can be used as a platform to implement continuous societal engagement and trust building in Society as the project aims at developing and implementing a transparent, transdisciplinary and science-based Risk Governance Framework (RGF) and related Council for managing nanotechnology risks regarding social, environmental and economic benefits. The project will work closely with other two projects: RiskGONE (https://riskgone.eu/) and Gov4Nano (https://www.gov4nano.eu/).
A new Horizon 2020 Project “NANORIGO: NANOtechnology RIsk Governance” officially launched during its kick-off meeting which was held on the 7th – 8th of February 2019 at Moesgaard Museum in Aarhus, Denmark.
The 4-year long, €4.7 million project is coordinated by Aarhus University from Denmark and received funding from the European Union’s Horizon 2020 Research and Innovation programme under the Grant Agreement nº 814530. NANORIGO project aims to develop and implement a transparent, transdisciplinary and active Risk Governance Framework (RGF) and establish the basis a related Council (RGC) for manufactured nanomaterials and nano-enabled products.
The RGF will be developed through engagement with stakeholders across research, industry, regulation and civil society, and will be based on high-quality scientific data and tools for the physicochemical characterization of nanomaterials, and the assessment of exposure, hazard and risk for humans and the environment.
The two-days meeting discussed in details each of the Work Package within the project, dissemination exploitation, and collaboration with other projects (including other governance projects), and implemented breakout group sessions for interrelated Work Packages.
The project will be started with an in-depth research on of risk management approach for nanotechnology; to integrate available knowledge on ethical, social, environmental and economic concerns into a user-friendly format that can be easily adapted and transferred into regulation for hazard, exposure and risk assessment and management of nanomaterials.
The expected results of
NANORIGO project are the following:
A transparent, self-sustained and science-based Risk Governance Council;
Transparent Risk Governance Framework (RGF) tools for managing possible nanotechnologies risks;
Availability of high quality data for decision making;
Consistency of approaches in all EU Member States and internationally.
The partnership of NANORIGO is involving 28 partners from 14 different European countries and a global advisory board. The partnership consists of the following organisations: Aarhus University (DK – Coordinator), Environmental Assessments (DE), Ecole Polytechnique Fédérale de Lausanne (CH), Tyoterveyslaitos (FI), Eidgenössischer Materialprüfungs- und forschungsanstalt (CH), Bundesanstalt für Materialforschung und –prüfung (DE), Instituto tecnológico del tmbalaje, transporte y logística (ES), ‘Fraunhofer Society; Institute for Molecular Biology & Applied Ecology’ (DE), Helmholtz-Centre for Environmental Research (DE), National Technical University of Athens (EL), Paris-Lodron-Universität Salzburg (AT), University of Bremen (DE), Universität für Bodenkultur Wien (AT), University of Aveiro (PT), Univerza v Ljubljani (SI), Transgero Ltd. (IE), Onderzoek en Adviesgroep Questions (NL), ‘Answers and More BV: Bureau KLB’ (NL), De Proeffabriek – Schuurbiers Daniel (NL), Engineering, Technical & Scientific Services (CH), ‘Society for Chemical Engineering and Biotechnology e.V – DECHEMA’ (DE), Optimat Ltd (UK), Sociedade Portuguesa de Inovação (PT), Fundación Gaiker (ES), Grupo Antolin Ingeniería (ES), ‘Oeko-Institut e.V. Institute for Applied Ecology (DE), European Environmental Citizen Organisations for Standardisation – ECOS (BE), Quercus ANCN (PT), and Women Engage for a Common Future France – WECF (FR).
The NANORIGO consortium will work closely with the two other projects funded under the NMBP-13-2018 call: RiskGONE (https://riskgone.eu/) and Gov4Nano (https://www.gov4nano.eu/), to ensure a sustainable and equitable RGF and NRGC is developed for all.
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